The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide-Doxorubicin Binding to DNA
Matrix metalloproteinases (MMPs) are extracellular matrix degradation elements, selling most cancers development. Therefore, they might present an enzyme-assisted supply of doxorubicin (DOX) in most cancers remedy. Within the present examine, the intercalation technique of DOX and tetrapeptide-DOX, the product of the MMPs’ cleavage of carrier-linked DOX, into dsDNA was investigated utilizing stationary and time-resolved fluorescence […]
